| Autor: |
Ruiz-Reig, Nuria, Rakotobe, Malalaniaina, Bethus, Ingrid, le Le Menn, Gwenael, Huditz, Hannah-Isadora, Marie, Helene, Lamonerie, Thomas, D'Autreaux, Fabien |
| Předmět: |
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| Zdroj: |
Journal of Neuroscience; 2/6/2019, Vol. 39 Issue 6, p1005-1019, 15p |
| Abstrakt: |
The habenulo-interpeduncular system (HIPS) is now recognized as a critical circuit modulating aversion, reward, and social behavior. There is evidence that dysfunction of this circuit leads to psychiatric disorders. Because psychiatric diseases may originate in developmental abnormalities, it is crucial to investigate the developmental mechanisms controlling the formation of the HIPS. Thus far, this issue has been the focus of limited studies. Here, we explored the developmental processes underlying the formation of the medial habenula (MHb) and its unique output, the interpeduncular nucleus (IPN), in mice independently of their gender. We report that the Otx2 homeobox gene is essential for the proper development of both structures. We show that MHb and IPN neurons require Otx2 at different developmental stages and, in both cases, Otx2 deletion leads to disruption of HIPS subcircuits. Finally, we show that Otx2 + neurons tend to be preferentially interconnected. This study reveals that synaptically connected components of the HIPS, despite radically different developmental strategies, share high sensitivity to Otx2 expression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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