| Autor: |
Goharian, Tina S., Fagerberg, Christina R., Jensen, Boye L., Graakjaer, Jesper, Brasch‐Andersen, Charlotte, Nybo, Mads |
| Zdroj: |
British Journal of Haematology; Mar2019, Vol. 184 Issue 5, p851-853, 3p, 1 Graph |
| Abstrakt: |
The article offers study which aimed to elucidate the physiological impact of a mono-allelic expression of null mutation of the gene encoding the EP3 receptor PTGER3 on platelet aggregation through Prostaglandin E2, an important inflammatory mediator produced by atherosclerotic plaques in healthy arterial walls. Topics include Array-comparative genomic hybridisation performed on two patients and reported a heterozygous deletion of PTGER3 in a mother and son with decreased platelet aggregation. |
| Databáze: |
Complementary Index |
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