| Autor: |
Bhandare, Sudhakar, Colom, Joan, Baig, Abiyad, Ritchie, Jenny M, Bukhari, Habib, Shah, Muhammad A, Sarkar, Banwarilal L, Su, Jingliang, Wren, Brendan, Barrow, Paul, Atterbury, Robert J |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; Mar2019, Vol. 219 Issue 5, p786-794, 9p |
| Abstrakt: |
Cholera remains a major risk in developing countries, particularly after natural or man-made disasters. Vibrio cholerae El Tor is the most important cause of these outbreaks, and is becoming increasingly resistant to antibiotics, so alternative therapies are urgently needed. In this study, a single bacteriophage, Phi_1, was used to control cholera prophylactically and therapeutically in an infant rabbit model. In both cases, phage-treated animals showed no clinical signs of disease, compared with 69% of untreated control animals. Bacterial counts in the intestines of phage-treated animals were reduced by up to 4 log10 colony-forming units/g. There was evidence of phage multiplication only in animals that received a V. cholerae challenge. No phage-resistant bacterial mutants were isolated from the animals, despite extensive searching. This is the first evidence that a single phage could be effective in the treatment of cholera, without detectable levels of resistance. Clinical trials in human patients should be considered. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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