| Autor: |
Sampaio, Fernanda A., Sampaio, Claudine R. A., Cunha, Carolina O., Costa, Yuri M., Alencar, Phillipe N. B., Bonjardim, Leonardo R., Garib, Daniela, Garlet, Gustavo P., Eliav, Eli, Conti, Paulo C. R. |
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| Zdroj: |
Journal of Oral Rehabilitation; Mar2019, Vol. 46 Issue 3, p257-267, 11p, 1 Diagram, 3 Charts, 2 Graphs |
| Abstrakt: |
Summary: Background: Although inflammation can alter cytokines release and nerve function, it is not yet fully established if orthodontic‐induced inflammation can cause significant extraoral trigeminal somatosensory alterations and release of inflammatory chemical mediators. Objective: The primary aim of this study was to investigate the impact of orthodontic separator and short‐term fixed orthodontic appliance on the extraoral trigeminal somatosensory function and concentrations of cytokines in the gingival crevicular fluid (GCF). Methods: Twenty‐two female patients were evaluated as follow: baseline, 24 hour‐after elastomeric separator (‐aES), 24 hour‐ and 1 month‐after bonding brackets (‐aBB) at both arches. The outcome variables were as follows: self‐reported pain (Visual Analog Scale), QSTs (current perception threshold‐CPT, cold detection threshold‐CDT, warm detection threshold‐WDT, mechanical detection threshold‐MDT, mechanical suprathreshold‐MST and wind‐up ratio‐WUR. All QSTs were performed at infra‐orbital and mental nerve entry zone at patient's dominant side. In addition, GCF samples in order to assess cytokines profile (IL‐1β,IL‐8,IL‐6 and TNF‐α) were collected. ANOVA and Tukey's post hoc analyses were performed (a = 5%). Results: Patients reported higher pain intensity 24 hour‐aBB compared to baseline and 24 hour‐aES (P < 0.050). Patients were less sensitive to pin‐prick pain (MST) at 24 hour‐aBB and 1 month‐aBB compared to baseline (P < 0.006). Significant increases in IL‐6 levels were observed 24 hour‐aBB (P < 0.001). Multiple comparison analysis showed significant increase in IL‐1β levels (P < 0.001) and TNF‐α (P < 0.001) 1 month‐aBB compared to baseline. Conclusion: Elastomeric separators only induced mild pain and were not able to significantly increase proinflammatory cytokines level in the GCF. In addition, orthodontic fixed appliance may induce only minor somatosensory changes at extraoral trigeminal locations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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