| Autor: |
Chandil, Nidhi, Pande, Shubha, Sen, Shashwati Sarkar, Gupta, Durgesh |
| Zdroj: |
Journal of Obstetrics & Gynecology of India; Feb2019, Vol. 69 Issue 1, p77-81, 5p |
| Abstrakt: |
Objective: Comparison of metformin and N acetylcysteine on clinical, metabolic parameter and hormonal profile in women with polycystic ovarian syndrome.Design: Prospective comparative study.Setting: Obstetrics and Gynecology department in Kamala Nehru Memorial Hospital Allahabad.Patient(s): On the basis of inclusion and exclusion criteria, 100 patients of PCOS were selected for study and assigned randomly in two groups to receive either metformin (1500 mg/day) (group M) or N acetylcysteine (1800 mg/day) (group N) for 24 weeks.Intervention(s): Metabolic parameter and hormonal profile were determined before and after the treatment.Main Outcome Measure(s): Metabolic parameters, fasting glucose, fasting insulin and testosterone changes.Result(s): Forty-five patients of both groups were ultimately evaluated. There was a significant improvement of body mass index, waist circumference and waist-hip ratio in group N, but there was no significant difference found in weight reduction among two groups. The biochemical marker of insulin resistance like fasting insulin, fasting glucose/insulin ratio improved significantly in group N. Greater reduction of total testosterone was observed in group N.Conclusion(S): Better improvement of metabolic and hormonal profile was observed in N acetylcysteine group. Because of its less side effect comparing to metformin, NAC can be used as a substitute for insulin-sensitizing agent in treatment of PCOS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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