| Autor: |
Steinebach, Christian, Kehm, Hannes, Lindner, Stefanie, Vu, Lan Phuong, Köpff, Simon, López Mármol, Álvaro, Weiler, Corinna, Wagner, Karl G., Reichenzeller, Michaela, Krönke, Jan, Gütschow, Michael |
| Předmět: |
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| Zdroj: |
Chemical Communications; 2/11/2019, Vol. 55 Issue 12, p1821-1824, 4p |
| Abstrakt: |
Small-molecule heterobifunctional degraders can effectively control protein levels and are useful research tools. We assembled proteolysis targeting chimeras (PROTACs) from a cereblon (CRBN) and a von-Hippel-Lindau (VHL) ligase ligand and demonstrated a PROTAC-induced heterodimerization of the two E3 ligases leading to unidirectional and efficient degradation of CRBN. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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