| Autor: |
Chen, Senhua, Shen, Hongjie, Zhang, Panpan, Cheng, Hongwei, Dai, Xingliang, Liu, Lan |
| Předmět: |
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| Zdroj: |
Chemical Communications; 2/4/2019, Vol. 55 Issue 10, p1438-1441, 4p |
| Abstrakt: |
Trichobamide A (1), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus Trichobotrys effuse 4729. Trichobamide A (1) showed significant inhibition of the proliferation of two glioma cell lines, U251 and SNB19. It induced the up-regulation of P53 expression, which in turn induces the up-regulation of downstream pro-apoptotic gene expression and the down-regulation of anti-apoptotic gene expression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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