| Autor: |
Wang, Qian, Jin, Bo, An, Gang, Zhong, Qian, Chen, Meijun, Luo, Xiaoying, Li, Zhilong, Jiang, Youjing, Liang, Weibo, Zhang, Lin |
| Předmět: |
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| Zdroj: |
International Journal of Legal Medicine; Jan2019, Vol. 133 Issue 1, p45-50, 6p |
| Abstrakt: |
Y-chromosomal short tandem repeats (Y-STRs) have been widely used in forensic analysis and population genetics. With low to moderate mutation rates, conventional Y-STR panels, including commercially available Y-STR kits, enable the identification of male pedigrees but typically fail to differentiate related male individuals. The introduction of rapidly mutating Y-chromosomal short tandem repeats (RM Y-STRs) with higher mutation rates (μ > 10−2) has been demonstrated to increase the discrimination capacity of unrelated men and the differentiation rate of related men compared with standard Y-STRs. To date, several studies have been performed worldwide. Here, 260 father-son pairs from Chinese Yi population were investigated, and 18.8% of them were differentiated with the 13 RM Y-STR markers, which was close to the theoretical estimate of 19.5% based on the mutation rates of these markers. Among the 57 mutations observed, repeat gains were more common than repeat losses (1.48:1), and one-step mutations were more common than two-step mutations (27.5:1). Locus-specific mutation rates ranged from < 3.85 × 10−3 (95% CI 0.00-1.41 × 10−2) to 3.85 × 10−2 (95% CI 1.86 × 10−2-6.96 × 10−2), with an average mutation rate of 1.46 × 10−2 (95% CI 1.11 × 10−2-1.89 × 10−2). Furthermore, we combined the father-son pair data from the present study with the data from the previous studies, generating an overall mutation rate of 1.70 × 10−2. The high differentiation rate obtained in the present study indicates the suitability of RM Y-STRs to distinguish paternal lineages in Chinese Yi population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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