Successful Treatment of Hepatitis C Virus by Ledipasvir/Sofosbuvir in a Cirrhotic Patient with Sickle Cell Disease and Thalassemia Minor.

Autor:	Al Moussawi, Hassan, Asti, Divya, Awada, Zainab, Polavarapu, Abhishek D., Mulrooney, Stephen
Zdroj:	Case Reports in Gastroenterology; 2018, Vol. 12 Issue 3, p629-632, 4p
Abstrakt:	Around 8% of patients diagnosed with sickle cell disease (SCD) are hepatitis C virus (HCV) carriers. Previously, HCV treatment was seldom considered in SCD patients, as the ribavirin-induced hemolysis and interferon-induced cytopenias could lead to more profound anemia. Nowadays, several oral direct-acting antiviral drugs have been developed and approved by the FDA for hepatitis C treatment. While direct-acting antivirals mitigate many of these risks, their safety and efficacy in SCD patients remains insufficiently explored. Here, we report on successfully treating HCV with ledipasvir/sofosbuvir in a compensated cirrhotic patient with SCD and thalassemia minor. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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