Tumor targeting with DGEA peptide ligands: a new aromatic peptide amphiphile for imaging cancers.

Autor: Zhan, Fu-Kai, Liu, Jyun-Cheng, Cheng, Bill, Liu, Yen-Chu, Lai, Tsung-Sheng, Lin, Hsin-Chieh, Yeh, Mei-Yu
Předmět:
Zdroj: Chemical Communications; 1/25/2019, Vol. 55 Issue 8, p1060-1063, 4p
Abstrakt: We report a novel fluorescent bioprobe, tetraphenylethylene-Phe-Asp-Gly-Glu-Ala (TPE-FDGEA), and its self-assembly behavior, photophysical properties, and biocompatibility. The hydrogelator TPE-FDGEA exhibited aggregation-induced emission characteristics, which facilitated imaging of PC-3 human prostate cancer cells, thereby demonstrating the utility of such fluorescent probes for specific labeling of target cells in vitro. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index