| Autor: |
Münscher, Adrian, Prochnow, Sebastian, Gulati, Amit, Sauter, Guido, Lörincz, Balazs, Blessmann, Marco, Hanken, Henning, Böttcher, Arne, Clauditz, Till Sebastian |
| Předmět: |
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| Zdroj: |
Clinical Oral Investigations; Jan2019, Vol. 23 Issue 1, p361-367, 7p, 1 Color Photograph, 1 Chart, 1 Graph |
| Abstrakt: |
Objectives: Strong expression of survivin is associated with worse survival in many different tumours, and in cell culture, a correlation between radiation resistance and survivin expression can be seen. The potential of survivin expression as a prognostic/predictive marker or therapeutic target has not been examined in head and neck squamous cell carcinomas (HNSCC) yet.Material and methods: Retrospective study of 452 tissue samples and clinical data from patients with squamous cell carcinomas of the larynx/hypopharynx (LSCC), oral cavity (OSCC) and oropharynx (OPSCC) treated in the University Medical Centre Hamburg-Eppendorf between 2002 and 2006. The expression patterns were detected by tissue microarray technique and correlated with clinical parameters (sex, age, tumour location, TNM 7th edition, grading, recurrence-free and overall survival).Results: 222 OSCC, 126 OPSCC and 105 LSCC tumours of 118 females and 335 males with a mean follow-up of 41.3 months were examined. Survivin expression correlates with pN, cM, pT and overall survival.Conclusion and clinical relevance: The potential of survivin as a prognostic/predictive marker is very high. The findings have to be confirmed in a larger cohort of HNSCC esp. in those tumours treated primarily with radio/radiochemotherapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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