| Autor: |
El‐Samahy, Mona H., Tantawy, Azza A., Adly, Amira A., Abdelmaksoud, Abeer A., Ismail, Eman A., Salah, Nouran Y. |
| Předmět: |
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| Zdroj: |
Pediatric Diabetes; Feb2019, Vol. 20 Issue 1, p65-72, 8p, 4 Charts, 1 Graph |
| Abstrakt: |
Background: Disturbances of glucose metabolism are common in β‐thalassemia major (β‐TM). Aim: This study was conducted to assess the pattern of glucose homeostasis in pediatric β‐TM patients comparing oral glucose tolerance test (OGTT) and continuous glucose monitoring system (CGMS). Methods: Two‐hundred β‐TM patients were studied and those with random blood glucose (RBG) ≥7.8 mmol/L (140 mg/dL) were subjected to OGTT, insertion of CGMS and measurement of fasting C peptide, fasting insulin, and hemoglobin A1c (HbA1c). Results: Twenty patients (10%) had RBG ≥ 7.8 mmol/L. Using OGTT, 6 out of 20 patients (30%) had impaired glucose tolerance (IGT) while 7 (35%) patients were in the diabetic range. CGMS showed that 7/20 (35%) patients had IGT and 13 (65%) patients had diabetes mellitus (DM); 10 of the latter group had HbA1c readings within diabetic range. The percentage of diabetic patients diagnosed by CGMS was significantly higher than that with OGTT (P = 0.012). Serum ferritin was the only independent variable related to elevated RBG. All β‐TM patients with DM were non‐compliant to chelation therapy. Conclusions: The use of CGMS in the diagnosis of early glycemic abnormalities among pediatric patients with β‐TM appears to be superior to other known diagnostic modalities. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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