| Autor: |
Larionov, L. P., Strekalov, I. M., Zuev, M. G., Dobrinskaya, M. N. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2019, Vol. 2063 Issue 1, p030011-1-030011-4, 4p, 5 Black and White Photographs, 1 Diagram |
| Abstrakt: |
Currently, iodine-containing compounds are used as x-ray contrast agents. Their significant drawback is the negative impact on the organs and systems of the human body. In this study, a new radiopaque agent, YTaO4 nanoparticles in a suspension of silicon dimethylglycerolate was investigated on three types of animals: outbred white mice, Wistar white rats, and Chinchilla rabbits. According to the results of toxicometry, observational data for the entire experimental period after a single and 30-day administration of the suspension, this new radiopaque substance can be attributed to class IV, almost non-toxic medicinal substances.The obtained results of studies of the radiopaque substance YTaO4 nanoparticles in suspension through various routes of administration confirmed. Its safety in the experimental conditions and sufficient X-ray contrast in subcutaneous and intramuscular injections. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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