| Autor: |
Nunes, Shirleide Santos, Fernandes, Renata Salgado, Cavalcante, Carolina Henriques, da Costa César, Isabela, Leite, Elaine Amaral, Lopes, Sávia Caldeira Araújo, Ferretti, Alice, Rubello, Domenico, Townsend, Danyelle M., de Oliveira, Mônica Cristina, Cardoso, Valbert Nascimento, de Barros, André Luís Branco |
| Zdroj: |
Drug Delivery & Translational Research; Feb2019, Vol. 9 Issue 1, p123-130, 8p |
| Abstrakt: |
Liposomes are lipid vesicles widely used as nanocarriers in targeted drug delivery systems for therapeutic and/or diagnostic purposes. A strategy to prolong the blood circulation time of the liposomes includes the addition of a hydrophilic polymer polyethylene glycol (PEG) moiety onto the surface of the vesicle. Several studies claim that liposome PEGylation by a single chain length or a combination of PEG with different chain lengths may alter the liposomes' pharmacokinetic properties. Therefore, the purpose of this study was to evaluate the influence of PEG on the biodistribution of pH-sensitive liposomes in a tumor-bearing animal model. Three liposomal formulations (PEGylated or not) were prepared and validated to have a similar mean diameter, monodisperse distribution, and neutral zeta potential. The pharmacokinetic properties of each liposome were evaluated in healthy animals, while the biodistribution and scintigraphic images were evaluated in tumor-bearing mice. High tumor-to-muscle ratios were not statistically different between the PEGylated and non-PEGylated liposomes. While PEGylation is a well-established strategy for increasing the blood circulation of nanostructures, in our study, the use of polymer coating did not result in a better in vivo profile. Further studies must be carried out to confirm the feasibility of the non-PEGylated pH-sensitive liposomes for tumor treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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