| Autor: |
Ziyatdinova, N. I., Kuptsova, A. M., Faskhutdinov, L. I., Zefirov, A. L., Zefirov, T. L. |
| Předmět: |
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| Zdroj: |
Bulletin of Experimental Biology & Medicine; Sep2018, Vol. 165 Issue 5, p593-596, 4p |
| Abstrakt: |
We studied the effect of α2-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α2-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10—6 M. Stimulation of α2-adrenergic receptors in concentrations of 10—8, 10—7, and 10—6 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10—6 M) caused a decrease in HR in one group and an increase in the other. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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