A Comparison of the Circular Dichroism Spectra of the Subclasses of Human Immunoglobulin G.

Autor: Johnson, P. M., Scopes, P. M., Tracey, B. M., Watkins, J.
Předmět:
Zdroj: Immunology; Jul74, Vol. 27 Issue 1, p27-31, 5p
Abstrakt: We have determined the circular dichroism of sixteen human IgG myeloma proteins, representative of the four subclasses. No significant variation in β structure was observed between the subclasses. However, at wavelengths greater than 230 nm, the spectra of IgG3 myeloma proteins is quite distinct, indicating a unique conformation. Myeloma proteins of the other subclasses gave similar overall spectra, but some of the features of the negative maxima in the region of 260-280 nm appeared to be subclass-specific. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index