Crohn's disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan.

Autor: Yasukawa, Shigeyoshi, Matsui, Toshiyuki, Yano, Yutaka, Sato, Yuho, Takada, Yasumichi, Kishi, Masahiro, Ono, Yoichiro, Takatsu, Noritaka, Nagahama, Takashi, Hisabe, Takashi, Hirai, Fumihito, Yao, Kenshi, Ueki, Toshiharu, Higashi, Daijiro, Futami, Kitaro, Sou, Suketo, Sakurai, Toshihiro, Yao, Tsuneyoshi, Tanabe, Hiroshi, Iwashita, Akinori
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Zdroj: Journal of Gastroenterology; Jan2019, Vol. 54 Issue 1, p42-52, 11p, 6 Charts, 1 Graph
Abstrakt: Background: In this study, survival and cause of death were investigated in patients with Crohn's disease (CD) at a tertiary referral center.Methods: A database was created based on the medical records of 1108 CD patients who had a history of visiting our hospital to investigate background characteristics, cumulative survival rates from diagnosis, causes of death, and the standardized mortality ratio (SMR) for each cause of death. A follow-up questionnaire survey of patients followed up inadequately was also conducted. The cumulative survival rate from diagnosis was determined using the life table method and compared with that of a sex- and age-matched population model from the year 2000.Results: The study included 1108 patients whose mean age at diagnosis was 25.6 ± 10.8 years. The mean duration of follow-up was 14.6 ± 9.4 years, and there were 52 deaths. The cumulative survival rate was significantly lower 25 years after the diagnosis of CD (91.7%) than in the standard population model (95.7%). SMRs for both all causes [3.5; 95% confidence interval (CI): 2.7-4.6] and CD-specific causes (36.7; 95% CI 26.1-51.6) were high. Among the CD-specific causes, SMRs were especially high for small intestine and colorectal cancers, gastrointestinal diseases including intestinal failure (IF), perioperative complications, and amyloidosis.Conclusion: The SMRs for both all causes and CD-specific causes were high in CD patients. CD-specific causes including intestinal cancer, IF, perioperative complications, and amyloidosis showed especially high SMRs. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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