The antibody response in BALB/c mice to the Plasmodium falciparum circumsporozoite repetitive epitope covalenty coupled to synthetic lipopeptide adjuvant.

Autor:	Wiesmüller, K.-H., Jung, G., Gillessen, D., Loffl, C., Bessler, W.G., Böltz, T.
Předmět:	PLASMODIUM falciparum MALARIA IMMUNOLOGICAL adjuvants EPITOPES ANIMAL models of immunology B cells IMMUNOGLOBULIN M IMMUNOGLOBULIN G LABORATORY mice
Zdroj:	Immunology; Jan1991, Vol. 72 Issue 1, p109-113, 5p
Abstrakt:	The repetitive epitope of Plasmodium falciparum circumsporozoite protein (Asn-Ala-Asn-Pro)3 [(NANP)3] was coupled to tripalmitoyl-S-glyceryl-cysteine (P3C) and tripalmitoyl-S-glycerylcysteinyl-serine (P3CS). The lipopeptide P3CS is a potent B-cell and macrophage activator. The resulting immunogenic lipopeptides were used for immunization of the low responder mouse strain BALB/c. These low molecular weight conjugates induced specific anti-(NANP)3 IgG and IgM levels without any carrier proteins or admixed adjuvants after a single administration. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu