Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Syzygium cumini Linn Leaves in Alloxan-Induced Diabetic Rats.
| Autor: | Ajiboye, Basiru O., Ojo, Oluwafemi A., Akuboh, Olivia S., Abiola, Okesola M., Idowu, Olajumoke, Amuzat, Aliyu O. |
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| Předmět: |
ANTI-inflammatory agents
HYPOGLYCEMIC agents LEAVES ANIMAL experimentation ANTIOXIDANTS BLOOD sugar DIABETES ENZYME-linked immunosorbent assay GLYCOGEN GLYCOSYLATED hemoglobin INSULIN INSULIN resistance LIPID peroxidation (Biology) PHOSPHATASES POLYPHENOLS RATS STATISTICAL sampling STATISTICS TRANSFERASES TUMOR necrosis factors PLANT extracts DATA analysis OXIDATIVE stress TREATMENT effectiveness METFORMIN DESCRIPTIVE statistics ONE-way analysis of variance THERAPEUTICS |
| Zdroj: | Journal of Evidence-Based Integrative Medicine; Dec2018, Vol. 23 Issue 1, p1-1, 1p |
| Abstrakt: | In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats were orally administered with 400 mg/kg free phenol, 400 mg/kg bound phenol, and 5 mg/kg metformin, respectively. On the 14th day of oral administration, the animals were sacrificed, anti-hyperglycemic and anti-inflammatory were assessed. Fasting blood glucose and glycated hemoglobin levels; homeostasis model assessment–insulin resistance scores, lipid peroxidation concentration, glucose-6-phosphatase activity, and all concentrations of anti-inflammatory studied in alloxan-induced diabetic rats were significantly (P < .05) reduced with the administration of polyphenolic-rich extract of Syzygium cumini leaves. Also there was significant (P < .05) increase in glycogen and insulin concentrations, pancreatic β-cell scores, antioxidant enzymes and hexokinase activities, as well as glucose transporter levels in diabetic animals administered with polyphenolic-rich extract of S cumini leaves. The results indicate that S cumini leaves possess anti-hyperglycemic and anti-inflammatory activities. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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