| Autor: |
Lane, P., Gerhard, W., Hubele, S., Lanzavecchia, A., McConnell, F. |
| Předmět: |
|
| Zdroj: |
Immunology; Sep93, Vol. 80 Issue 1, p56-61, 6p |
| Abstrakt: |
We report the construction and expression of a fusion protein made from the extracellular portion of the mouse CTLA-4 gene and the constant region of human IgG1. This fusion protein behaves like an antibody to mouse B7/BB1, binding to activated B cells and purified dendritic cells. In addition, we found it to bind to activated T cells. The fusion protein interfered with the ability of antigen-pulsed antigen-presenting cells to induce proliferation of T-cell clones, although the degree of inhibition varied. These findings are discussed in the light of the physiological activation oft cells in secondary lymphoid organs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
