| Autor: |
Боцова, В., Сабри, А., Костадинова, Е., Елкина, С., Петрова, Ч. |
| Zdroj: |
Pediatria; 2018, Vol. 58 Issue 3, p10-13, 4p |
| Abstrakt: |
Acute kidney injury /AKI/ is defined as a rapid and reversible loss of renal function, leading to increased concentration of nitrogenous waste products in the blood and inability of kidneys to regulate fluid and electrolyte homeostasis. AKI is a common problem in medical practice. The diagnosis of AKI is usually based on increased serum creatinine levels, though they are an unreliable indicator of acute deterioration of kidney function as the changes in serum creatinine occur 48-72 hours after renal injury. Many studies have now implicated NGAL as a new highly sensitive and specific biomarker for identification of early stages of AKI. The aim of our study is to investigate the ability of NGAL as a novel diagnostic and prognostic indicator for AKI in pediatric practice. It was made a review of the literature about the role of NGAL for early diagnosis of AKI in children with different conditions such as cardiac surgery, acute urinary tract infections, sepsis, contrast-induced nephropathy and kidney transplantation. As a conclusion we can consider that the use of NGAL measurement in urine and plasma as early marker of AKI is important for protection of renal function and better prognosis [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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