| Autor: |
Silva, C. L., Silva, M. F., Pietro, R. C. L. R., Lowrie, D. B. |
| Předmět: |
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| Zdroj: |
Immunology; Nov94, Vol. 83 Issue 3, p341-346, 6p |
| Abstrakt: |
We have previously shown that mice vaccinated by injection with J774 macrophage-like tumour cells that expressed Mycobacterium leprae heat shock protein (hsp) 65 as a transgene had acquired a remarkably high degree of protection against subsequent challenge with virulent M. tuberculosis. We show here that antigen-specific T cells cloned from spleens of such vaccinated animals can transfer a high level of protection to non-vaccinated recipients. The most efficient cells were of T cell receptor (TCR)αβ+ and CD4- CD8+ type and specifically lysed mycobacteria-infected macrophages. These findings are consistent with the importance for protective immunity of engaging the endogenous antigen-presenting pathway to bias the immune response towards a cytolytic action against a mycobacterial antigen that is expressed at the surface of infected macrophages. TCR γδ+ and TCR αβ+ cells interacted synergistically. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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