| Abstrakt: |
Five new platinum(II) complexes bearing a eugenol and a quinoline derivative, namely [η2‐4‐allyl‐2‐methoxy‐1‐(propoxycarbonylmethoxy)benzene]‐trans‐dichlorido(quinoline‐κN)platinum(II), [PtCl2(C15H20O4)(C9H7N)], (2), {η2‐4‐allyl‐2‐methoxy‐1‐[(propan‐2‐yloxy)carbonylmethoxy]benzene}‐trans‐dichlorido(quinoline‐κN)platinum(II), [PtCl2(C15H19O4)(C9H7N)], (3), [η2‐4‐allyl‐2‐methoxy‐1‐(propoxycarbonylmethoxy)benzene]chlorido(quinolin‐8‐olato‐κ2N,O)platinum(II), [Pt(C9H6NO)Cl(C15H20O4)], (4), {η2‐4‐allyl‐2‐methoxy‐1‐[(propan‐2‐yloxy)carbonylmethoxy]benzene}chlorido(quinolin‐8‐olato‐κ2N,O)platinum(II), [Pt(C9H6NO)Cl(C15H20O4)], (5), and [η2‐4‐allyl‐2‐methoxy‐1‐(propoxycarbonylmethoxy)benzene]chlorido(quinolin‐2‐carboxylato‐κ2N,O)platinum(II), [Pt(C10H6NO2)Cl(C15H20O4)], (6), have been synthesized and fully characterized spectroscopically. A single‐crystal X‐ray diffraction study was carried out for complexes (2) and (4)–(6). PrEug [or 4‐allyl‐2‐methoxy‐1‐(propoxycarbonylmethoxy)benzene] in (2), (4) and (6), and iPrEug (the propan‐2‐yloxy analogue of PrEug) in (3) and (5) coordinate with PtII at the ethylenic double bond of the allyl group. In (2)–(6), the donor N atom of the amine group occupies a trans position with respect to the double bond. A comparison of the IC50 values of 0.38–29.23 µM for (2)–(6) with cisplatin, as well as other platinum(II) complexes, indicates an excellent in vitro cytotoxicity against the KB, LU, Hep‐G2 and MCF‐7 cancer cell lines, with the highest cytotoxic effect (IC50 = 0.38–1.99 µM) being for complexes (4) and (5) bearing a quinolin‐8‐olate ligand. The syntheses and structures of five new platinum(II) complexes bearing (iso)propyl eugenoxyacetate and quinolines are presented, as well as their in vitro cytotoxicity on four human cancer cell lines. [ABSTRACT FROM AUTHOR] |
