| Autor: |
de Andrade, Vitor S. C., de Mattos, Marcio C. S. |
| Předmět: |
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| Zdroj: |
Synthesis; 2018, Vol. 50 Issue 24, p4867-4874, 8p |
| Abstrakt: |
A simple and efficient one-pot protocol has been developed for the synthesis of thiazole derivatives from readily available starting materials. Tribromoisocyanuric acid was successfully used for a-monohalogenation of ß-keto esters in aqueous medium, which in the presence of thiourea and DABCO produced the corresponding 2-aminothiazoles in up to 87% yield. Extension of the reaction to thioacetamide and o-phenylenediamine led to 2-methylthiazole and quinoxalines, respectively. This approach enables telescoping of the two steps into a single process. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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