| Autor: |
Vallotto, Claudio, Shaili, Evyenia, Shi, Huayun, Butler, Jennifer S., Wedge, Christopher J., Newton, Mark E., Sadler, Peter J. |
| Předmět: |
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| Zdroj: |
Chemical Communications; 12/21/2018, Vol. 54 Issue 98, p13845-13848, 4p |
| Abstrakt: |
l-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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