HLA‐A, ‐B, ‐DRB1, ‐DQA1, and ‐DQB1 profile in a population from southern Brazil.

Autor: Reis, Pâmela G., Ambrosio‐Albuquerque, Eliane P., Fabreti‐Oliveira, Raquel A., Moliterno, Ricardo A., de Souza, Victor H., Sell, Ana M., Visentainer, Jeane E. L.
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Zdroj: HLA: Immune Response Genetics; Nov2018, Vol. 92 Issue 5, p298-303, 6p, 1 Chart, 2 Graphs, 1 Map
Abstrakt: The aim of this study was to determine the allele and haplotype frequencies of HLA‐A, ‐B, ‐DRB1, and ‐DQB1 in a self‐declared White population from the north and northwestern state of Paraná, southern Brazil, and compare the data with populations worldwide. The genotyping was performed with a group of 641 individuals, based on PCR‐SSO and ‐SSP methods, and allele and haplotype frequencies were estimated. Comparisons with European, African, Asian, and Amerindian populations were performed. The most frequent allelic groups, alleles and haplotypes were: HLA‐A*02, HLA‐B*35, HLA‐DRB1*07:01, HLA‐DQB1*03:01, and HLA‐A*01/B*08/DRB1*03:01. The results reinforced a predominance of a European composition in the self‐declared White population from the north and northwestern Paraná. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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