Abstrakt: |
Background: CD10 is a cell surface zinc-dependent enodpepitdase and its expression in tumor stroma is thought to be associated with biological aggressiveness of many epithelial malignancies. Objectives: To estimate the frequency of stromal CD10 expression in invasive breast cancer and its correlation to clinicopathological data including immunohistochemical markers. Methods: This study included 102 cases of invasive breast carcinoma. CD10 expression was assessed by immunohistochemistry and scored as negative, weak and strong positive and the results were statistically analyzed in correlation to various clinical and pathological parameters in addition to other immunohistochemical markers. Results: CD 10 was found to be positive in 58/102 cases (56.8%). Stromal CD10 showed significant correlation with the T parameter of the TNM staging system (p=0.043), dermal infiltration (p=0.049) and estrogen receptor positivity (p=0.039), while there was no significant correlation with the patients' age (p=0.20), tumor grade (p=0.294), and lymph node status (p=0.29). Conclusion: Stromal CD10 was expressed in more than half of cases with invasive breast carcinoma, and there was a significant correlation of the stromal CD 10 expression with the T parameter of the TNM staging system, dermal infiltration and the positivity of estrogen receptor expression and no correlation was found between stromal CD10 expression and patients' age, tumor grade, stage, lymph node status, lymphovascular invasion, perineural invasion, Paget's disease of the nipple, progesterone receptors expression and HER2/Neu status. [ABSTRACT FROM AUTHOR] |