| Autor: |
Sudprasert, Weera, Terdpong Tanaviriyachai, Kongtush Choovongkomol, Jongkittanakul, Sarut, Piyapromdee, Urawit |
| Předmět: |
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| Zdroj: |
Journal of the Medical Association of Thailand; 2018 Supplement, Vol. 101, pS15-S22, 8p |
| Abstrakt: |
Background: There is limited literature regarding the topical use of tranexamic acid [TXA] to control postoperative bleeding in posterior spinal fusion [PSF] procedures, operations which often required blood transfusions. Objective: To evaluate the effect of topically applied TXA on postoperative blood loss in patients undergoing conventional open PSF surgeries. Materials and Methods: A retrospective study was conducted on a total of 73 patients who had spinal injuries of the thoracolumbar vertebrae and who had undergone long-segment instrumented PSF without decompression between January 2011 and April 2015. Thirty-five patients were assigned to be given topical TXA (1 g/20 mL) and then their drain was clamped for 2 hours. Thirty-eight patients in the control group were treated using similar procedures but with continuous drainage and without antifibrinolytic agents. Results: The rate of postoperative packed red cells [PRC] transfusion was significantly lower in the topical TXA group than in the control group (11.4% vs. 44.7%;p = 0.002; relative risk, 0.26; 95% confidence interval, 0.1 to 0.69). Median drainage blood loss, median days to drain removal and median postoperative hospitalization were significantly less in the topical TXA group (p<0.05). Multinomial logistic regression analysis indicated that the use of topical TXA was a significant factor in reducing the rate of postoperative PRC transfusion (p = 0.004). Conclusion: The use oftopically administered 1 g TXA in thoracolumbar spinal trauma cases undergoing PSF with longsegment instrumentation reduces postoperative transfusion requirements, decreases the total amount of drainage blood loss, lessen the time to drain removal and shortens the period of postoperative hospitalization. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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