| Autor: |
Ganimedov, V. L., Larionov, P. M., Maslov, N. A., Tsibulskaya, E. O. |
| Zdroj: |
AIP Conference Proceedings; 2018, Vol. 2036 Issue 1, p030020-1-030020-7, 7p |
| Abstrakt: |
The purpose of the simulated reactor is a production of tissue-engineered structures, designed for regeneration of bone tissue outside the body. The rotational reactor used in clinical practice is taken as a basis. Its geometric data, the mathematical model and the results of the computation experiments are given in [1, 2]. In [3], a comparison is made between the results of a numerical calculation and the experimental data on laser visualization of a flow in the rotational reactor. In the present paper, the modification of rotational reactor is considered, which makes it possible to change the hydrodynamic flow regime around the biological material. In the new setup the rotation axis of the inner cylinder is parallel shifted from the axis of symmetry of the outer cylinder at a distance of 12.5% of the radius. As a result, the radial gap between the outer stationary and inner rotating cylinders depends on the circumferential coordinate φ. The variable gap has become a factor determining the formation flow fields in reactor working zone. The effect of the fluid flow on the cellular material adhered on the scaffold surface, which in turn is fixed on the surface of the rotating cylinder, has become variable in magnitude and cyclic in shape. The computational algorithm for solving the problem is based on packet technology. The numerical solution is based on the gas-dynamic solver FLUENT of the ANSYS 12 software package. The flow regime in the boundary layer is postulated to be laminar. A series of parametric calculations was performed for the rotation frequency of the inner cylinder f in the range 0.083 ≤ f ≤ 0.167 Hz. The work presents visualization of the velocity fields and distribution of shear stress and static pressure on the rotating cylinder surface. It is shown that the cyclicity of the hydrodynamic effect on the working zone expands the range of possibilities of rotational bioreactors for the bone tissue cultivation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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