Multicomponent transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, and pyrazolin-5-ones into substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles.

Autor:	Elinson, M. N., Vereshchagin, A. N., Anisina, Y. E., Goloveshkin, A. S., Ushakov, I. E., Egorov, M. P.
Předmět:	PYRAZOLINONES CARBONITRILES TRIETHYLAMINE METAL catalysts MOIETIES (Chemistry) SUBSTITUENTS (Chemistry)
Zdroj:	Russian Chemical Bulletin; Sep2018, Vol. 67 Issue 9, p1695-1703, 9p
Abstrakt:	A new multicomponent reaction, namely, a one-pot transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, and 2-pyrazolin-5-ones in the presence of triethylamine as the catalyst in a minimum amount of propanol leads to the previously unknown substituted 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno [2,3-b]- pyridine-3-carbonitriles in 63-98% yields. This reaction provides a facile and efficient route to a new type of functionalized 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine systems containing the 2-pyrazolin-5-one moiety. These reaction products are promising compounds for different biomedical applications. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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