| Autor: |
Hellerstein, Stanley, Berenbom, Max, Erwin, Pat, Wilson, Nancy, DiMaggio, Sylvia |
| Předmět: |
|
| Zdroj: |
Pediatric Nephrology; May2004, Vol. 19 Issue 5, p521-525, 5p |
| Abstrakt: |
Glomerular filtration rate (GFR) and urine and serum concentrations of cystatin C and creatinine were measured in 40 boys and 42 girls. The fractional excretion of cystatin C (FE Cyst C) increased in proportion to the decrease in GFR. Since serum creatinine concentration (S-Creatinine) in the numerator of the fractional excretion equation and serum cystatin C concentration (S-Cystatin C) in the denominator have similar numerical values, they cancel out. The result is an equation in which the FE Cyst C is equal to the ratio of urinary cystatin C to urinary creatinine (u[cystatin-C/Cr]). The ratio of u[cystatin Cl Cr] was compared with GFR. Using a receiving operating characteristic (ROC) plot, the data showed that a ratio of u[cystatin C/Cr]*I00 that is ≥0.100 has a sensitivity of 90.0% for identification of children with GFR ≤60 ml/min per 1.73 m². The false-positive rate is 16.1%. The u[cystatin C/Cr] ratio is a reliable screening tool for detecting decreased GFR that does not require a serum sample. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
