| Autor: |
Kotel’nikova, O. V., Alliluev, A. P., Zinchenko, A. A., Prokopenko, Yu. A., Zhigis, L. S., Zueva, V. S., Razgulyaeva, O. A., Gordeeva, E. A., Melikhova, T. D., Nokel’, E. A., Rumsh, L. D. |
| Předmět: |
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| Zdroj: |
Bulletin of Experimental Biology & Medicine; Oct2018, Vol. 165 Issue 6, p763-766, 4p |
| Abstrakt: |
We studied immunogenicity of two recombinant proteins FR.9 and FR.11-3 created on the basis of fragments of the primary structure of N. meningitidis IgA1 protease with different molecular weights containing different sets of T and B epitopes. The proteins actively protect animals infected with live virulent culture of meningococci, serogroups A, B, and C. Analysis of CD4+, CD8+, and CD19+ lymphocyte populations in mouse blood showed predominant contribution of different cell populations to the formation of immune response to different proteins. Injection of FR.11-3 protein to animals did no affect the immunoregulatory index, hence, this protein can be used for creation of immunologically safe vaccine preparation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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