| Autor: |
Fitriastuti, Dhina, Nur Iman, Annisa Wahyu, Lutfiani, Dea Alvine, Yuliyanti, Dian |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2018, Vol. 2026 Issue 1, p020105-1-020105-7, 7p |
| Abstrakt: |
Curcuma mangga, locally known as "temu mangga" or "kunyit mangga", is a rhizomatous herb of the Zingiberaceae family. The rhizomes of C. mangga are used in Java as a seasoning for food and treatment for stomach aches, fever and cancer-related diseases. In the present paper, the antiplasmodial activity of extract and fraction of C. mangga rhizome has been conducted. The rhizome was extracted with ethanol by using soxhletation extraction. The ethanol extract was fractioned by using Vacuum Liquid Chromatography (VLC) method with eluent of n-hexane:ethyl acetate (2:1), ethyl acetate and ethanol. The extract and fraction were analyzed by using GC-MS. From the GC-MS data, it is showed that the extract and fraction contained (E) -labda-8 (17), 12-dien-15,16-dial compound which is known have a good anticancer activity. This compound is high percentage contained in ethanol extract and n-hexane:ethyl acetate (2:1) fraction. Thus, the antiplasmodial assay was tested in the both samples. The result of antiplasmodial assay showed that n-hexane:ethyl acetate (2:1) fraction could inhibit the parasitemia growth in 10 μg/mL of dosage with the average inhibition of 8.42% while the ethanol extract in 10 μg/mL of dosage could not inhibit the growth of parasitemia. Ethanol extract and n-hexane:ethyl acetate (2:1) fraction have IC50 values of 62.64 μg/mL and 46.17 μg/mL, respectively. Thus, the n-hexane:ethyl acetate (2:1) fraction displayed better antimalarial activity than ethanol extract. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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