| Autor: |
Adebayo, Abiodun Humphrey, Yakubu, Omolara Faith, Popoola, Jacob O., David, Lawrence Chibuike, Okenze, Gloria, Agbafor, Amarachi Grace, Okubena, Olajuwon |
| Předmět: |
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| Zdroj: |
Comparative Clinical Pathology; Nov2018, Vol. 27 Issue 6, p1595-1601, 7p |
| Abstrakt: |
The rate of increasing resistance to most antimalarial drugs suggests a need for better alternatives. Hence, the present study evaluates the in vivo antimalarial and biochemical profiles of a locally formulated herbal antimalarial therapy, Abaleria® on mice infected with Plasmodium berghei. Eight groups of five mice each were used. The control groups include uninfected, infected with 1.0 × 107P. berghei parasites but not treated, infected, and treated 3 days after inoculation with 25 mg kg−1 chloroquine diphosphate (CDP). Other groups were infected and treated with 50, 100, 200, 300, and 500 mg kg−1/day of Abaleria® for 4 days. On the 5th day, blood smears were prepared and evaluated for parasitemia microscopically, and animals were thereafter sacrificed; serum obtained from blood samples collected through cardiac puncture was used for biochemical assays. There was a significant (p < 0.05) reduction in parasitemia at the highest dose of the drug which compared favorably with CDP. Infection led to elevated liver function indices while treatment with Abaleria® normalized these parameters; a dose dependent increase in HDL-cholesterol was detected in the groups treated with Abaleria® and CDP. The study shows that Abaleria® displayed a dose-dependent in vivo antiplasmodial and biochemical properties as well as improvement of lipid profiles of mice infected with P. berghei. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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