Correlation of Maternal Stress Because of Positive Aneuploidy Screening Serum Analytes and Uterine Arteries' Doppler Ultrasound Index: A Prospective Cohort Study.

Autor:	Shirazi, Mahboobeh, Pooransari, Parichehr, Sharbaf, Fatemeh Rahimi, Niromanesh, Shirin, Sahebdel, Behrokh, Shariat, Mamak, Pahlavan, Zeinab, Shirazi, Mahmoud, Ahmadian, Maryam
Předmět:	ANXIETY diagnosis PSYCHOLOGICAL stress DOPPLER ultrasonography AFFECT (Psychology) ALPHA fetoproteins AMNIOCENTESIS ANEUPLOIDY BLOOD circulation CHORIONIC gonadotropins LONGITUDINAL method PREGNANT women PRENATAL diagnosis PSYCHOLOGICAL tests UTERUS PILOT projects ATTITUDES of mothers STATE-Trait Anxiety Inventory ESTRIOL DIAGNOSIS
Zdroj:	International Journal of Fertility & Sterility; Jan-Ma2019, Vol. 12 Issue 4, p329-334, 6p, 5 Charts
Abstrakt:	Background: Antenatal anxiety or maternal stress is a prevalent chronic mental disorder in pregnant women. We have assessed the effect of maternal stress from positive aneuploidy screening results on the changes in uterine artery blood flow. Materials and Methods: We performed a prospective cohort (one sample) pilot study at a hospital in Tehran, Iran. A total of 60 pregnant women who were candidates for amniocentesis due to abnormal sequential screening test results entered the study. We conducted 2 standard psychological tests, the Spielberger's State-Trait Anxiety Inventory and the Beck Anxiety Inventory, to determine anxiety levels in the participants before amniocentesis and two weeks after amniocentesis. The uterine artery resistance index was also measured before and two weeks after amniocentesis. The level of maternal stress was compared with the uterine artery resistance index. Results: Patients had a mean State Trait Anxiety Inventory score before amniocentesis of greater than 40, which meant that the mothers experienced high anxiety. There were no correlations between both inventories' anxiety scores and uterine artery blood flow before amniocentesis. However, two weeks after amniocentesis, we observed significant negative correlations between the State Anxiety (P=0.0041) and Trait Anxiety (P=0.010) Inventory scores and the uterine artery resistance indexes. Also, there was an association between the decreased right uterine artery resistance index and State Anxiety scores (P=0.036). There were significant correlations between State and Trait Anxiety scores and second trimester analytes of β-human chorionic gonadotropin (β-hCG, P<0.001), α-fetoprotein (P<0.001), and unconjugated estriol (P=0.048). Conclusion: Maternal anxiety because of positive aneuploidy screening serum analytes and amniocentesis can affect perinatal outcomes via mood-based alterations in blood flow of the uterine arteries and the screening markers β-hCG,unconjugated estriol, and α-fetoprotein. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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