| Abstrakt: |
The aim of the study was to explore the prevalence of mycogenic sensitization in arterial hypertension (AH) and its relationship with the disease severity, progression of chronic heart failure (CHF) and contractilic function of myocardium. 44 patients with stages II and III of AH and functional classes IIIII of CHF by NYHA (mean age 62.3 ± 1.7 years, 24 males and 20 females) were tested for the presence of mycogenic sensitization. The levels of serum specific IgE antibodies (sIgE) against Candida maltosa, Saccharomyces cerevicae, Candida albicans, Candida crusei, Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Penicillium chrysogenum, Penicillium tardum, Penicillium expansum, Alternaria tenuis, Trichophyton rubrum, Fusarium oxysporum, Cladosporium herbarum, Rhizopus nigricans, Mucor pusillus were measured by ELISA. The presence of mycogenic sensitization was determined at the level of sIgE > 50 kU/l. Results. The presence of IgE-mediated hypersensitivity to fungal antigens was revealed in 40.9% of patients with AH. In patients with III stage of AH, in comparison to the patients with II stage of AH, a greater prevalence and severity of mycogenic sensitization were noted, as well as a poly-sensitization to fungi of Aspergillus, Candida and Alternaria species, in particular to Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus, Candida maltosa, Candida albicans and Alternaria tenuis. Progression of CHF, as well as worsening of the contractility of myocardium, was associated with increased mycogenic sensitization to this spectrum of fungi. Moreover, patients with decreased systolic function of myocardium were characterized not only by a greater prevalence of increased sIgE against Aspergillus, Candida and Alternaria species (in particular to Aspergillus niger and Alternaria tenuis), but also by a higher incidence of paucisensitization of high degrees. Conclusions. Mycogenic sensitization to Aspergillus, Candida and Alternaria species might be considered as a risk factor for cardiovascular complications in arterial hypertension. [ABSTRACT FROM AUTHOR] |
