| Autor: |
Das, Soumen, Mathur, Anupam, Nair, Preethi, Vanaja, R., Sachdev, S. S. |
| Předmět: |
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| Zdroj: |
Journal of Radioanalytical & Nuclear Chemistry; Nov2018, Vol. 318 Issue 2, p1287-1295, 9p, 6 Graphs |
| Abstrakt: |
99mTc-ethylene dicysteine diethyl ester (99mTc-ECD) is an established radiopharmaceutical used for brain perfusion imaging; however it does not have any recognized biological quality control to ascertain its in vivo efficacy. The present paper describes an in vitro enzymatic method that can be adapted as a regular biological quality control for ECD kit evaluation before its release for patient end use. The method involves reaction of 99mTc-ECD (< 74 MBq; 0.1 mg ECD) with pig liver esterase enzyme (≥ 20 mg/mL) yielding metabolites in quantitative yield post 1 h incubation. Methodology developed is precise for routine quality control analyses of ECD kits. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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