| Autor: |
Lafaurie, GI, Zaror, C, Díaz‐Báez, D, Castillo, DM, De Ávila, J, Trujillo, TG, Calderón‐Mendoza, J |
| Předmět: |
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| Zdroj: |
International Journal of Dental Hygiene; Nov2018, Vol. 16 Issue 4, p527-534, 8p, 1 Color Photograph, 1 Diagram, 2 Charts, 2 Graphs |
| Abstrakt: |
Background: Hypochlorous acid (HOCl) is a non‐antibiotic antimicrobial substance with significant effects on pathogenic oral micro‐organisms. The effects of HOCl as an antiplaque agent have not been studied. Objective: The aim of this study was to evaluate the substantivity of HOCl mouthwashes compared with chlorhexidine (CHX) rinses and a placebo. Materials and Methods: A double‐blind randomized controlled trial with 75 participants was conducted. Participants were divided into five groups using block randomization: 0.025% HOCl, 0.05% HOCl, 0.12% CHX, 0.2% CHX, and sterile water as a placebo. Participants were instructed to use each rinse solution for 30 seconds after dental prophylaxis. Samples of saliva were taken at baseline and after 30 seconds, 1, 3, 5 and 7 hours to assess substantivity, and bacterial viability was established by the fluorescence method. Visible plaque in all participants was assessed with the Turesky index at baseline and at 7 hours, and adverse events were also assessed. Results: HOCl led to a 33% reduction in bacterial counts in the saliva after 30 seconds compared with a 58% reduction by CHX. HOCl has no substantivity, and bacterial counts returned to baseline after 1 hour. Placebo treatment led to the highest plaque count after 7 hours compared with the CHX and HOCl groups, although the differences were not significant. HOCl rinsing induced the highest percentages of unpleasant taste and dryness sensations. Conclusions: HOCl rinses have an initial effect on bacterial viability in saliva but have no substantivity. Other mechanisms may explain its antiplaque effect. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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