| Autor: |
Shek, F. W., Li, K. F., Mann, J., Williams, E. J., Iredale, J. P., Beynon, R. C., Fine, D. R. |
| Předmět: |
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| Zdroj: |
Gut; Apr2004 Supplement 3, Vol. 53, pA16-A16, 1/4p |
| Abstrakt: |
Pancreatic stellate cells (PSC) play an important role in the production of extracellular matrix in pancreatic fibrosis. In contrast to TGF-β1, TGF-β3 appears to have anti-scanning properties in cutaneous wound healing. The study examined the role of TGF-β3 in the deposition of collagen and the balance of the metalloproteinases (MMP) and tissue inhibitors of metalloproteinases in PSC. The results suggest that TGF-β3 possesses anti-fibrotic properties in PSC by reducing collagen secretion; and by decreasing this potent MMP inhibitor, TIMP-1 mRNA expression. This is the first description of anti-fibrotic action by TGF-β3 in a non-cutaneous system. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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