A case of idiopathic pulmonary alveolar proteinosis accompanied by T-cell receptor gene rearrangement in bronchoalveolar lavage fluid cells.

Autor:	Hosokawa, Takeshi, Yamaguchi, Etsuro, Shirai, Shinya, Fuke, Satoshi, Takaoka, Kazuo, Kojima, Jun-Ichiro, Nakata, Koh, Nishimura, Masaharu
Předmět:	PULMONARY alveoli T-cell receptor genes BRONCHOALVEOLAR lavage SILICOSIS DUST diseases GRANULOCYTE-macrophage colony-stimulating factor DISEASES
Zdroj:	Respirology; Jun2004, Vol. 9 Issue 2, p286-288, 3p
Abstrakt:	A case of idiopathic pulmonary alveolar proteinosis accompanied by T-cell receptor gene rearrangement in bronchoalveolar lavage fluid cells HOSOKAWA T, YAMAGUCHI E, SHIRAI S, FUKE S, TAKAOKA K, KOJIMA J, NAKATA K, NISHIMURA M. Respirology 2004; 9: 286–288 We describe a case of a patient with idiopathic pulmonary alveolar proteinosis (PAP), who had an elevated serum level of antigranulocyte-macrophage colony stimulating factor (anti-GM-CSF) antibody accompanied by T-cell receptor gene rearrangements in BAL fluid cells. Histopathological examination of the lung excluded lymphoma but revealed PAP and silicosis. There was no detectable serum anti-GM-CSF antibody in 50 outpatients with advanced silicosis who did not have PAP, suggesting that anti-GM-CSF antibody is directly linked to PAP but not to silicosis. We speculate that monoclonal expansion of a T-cell population may play a role in the production of anti-GM-CSF antibody and the development of PAP. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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