αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family.

Autor: Chiarella, Sergio E., Rabin, Erik E., Ostilla, Lorena A., Flozak, Annette S., Gottardi, Cara J.
Předmět:
Zdroj: Tissue Barriers; 2018, Vol. 6 Issue 2, p1-N.PAG, 12p
Abstrakt: α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index