Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis.

Autor:	Tao, Ye, Gilbertson, Scott R.
Předmět:	INDOLINE SULTAMS SUBSTITUTION reactions
Zdroj:	Chemical Communications; 10/14/2018, Vol. 54 Issue 80, p11292-11295, 4p
Abstrakt:	The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99 : 1 d.r.). [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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