| Autor: |
Ito, Seigo, Uchida, Takahiro, Oshima, Naoki, Oda, Takashi, Kumagai, Hiroo |
| Předmět: |
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| Zdroj: |
BMC Nephrology; 10/4/2018, Vol. 19 Issue 1, pN.PAG-N.PAG, 1p |
| Abstrakt: |
Background: The pathophysiologic role of exogenous granulocyte-colony stimulating factor (G-CSF) administration is reportedly linked to the progression of glomerulonephritis. However, the relationship between endogenous G-CSF overproduction and the progression of glomerulopathy has not been well investigated.Case Presentation: A 76-year-old woman presented with neutrophilia at a medical check-up and thorough examination revealed a high level of serum G-CSF. She subsequently developed mild renal dysfunction and proteinuria. Her renal biopsy showed lobulation of the glomeruli with mesangial proliferation and glomerular capillary walls with a double contour but no immune complex deposition, suggesting membranoproliferative glomerulonephritis-like glomerulopathy. Thereafter, her proteinuria levels fluctuated in parallel with the changes in her blood neutrophil count and finally reduced considerably in association with her decreased neutrophil count.Conclusions: The unique features of this case suggest that endogenous overproduction of G-CSF could play an important role in the pathogenesis of active glomerulonephritis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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