Lower In-Hospital Ventricular Tachyarrhythmia in Patients With Acute Myocardial Infarction Receiving Prior Statin Therapy.
| Autor: | Park, Jin Sup, Kim, Bo Won, Hong, Taek Jong, Choe, Jeong Cheon, Lee, Hye Won, Oh, Jun-Hyok, Choi, Jung Hyun, Lee, Han Cheol, Cha, Kwang Soo, Jeong, Myung Ho |
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| Předmět: |
MYOCARDIAL infarction treatment
VENTRICULAR fibrillation VENTRICULAR tachycardia STATINS (Cardiovascular agents) CONFIDENCE intervals REPORTING of diseases RISK management in business TREATMENT effectiveness DISEASE incidence HOSPITAL mortality ODDS ratio PERCUTANEOUS coronary intervention PREVENTION DISEASE risk factors |
| Zdroj: | Angiology; Nov2018, Vol. 69 Issue 10, p892-899, 8p |
| Abstrakt: | We evaluated whether prior statin therapy reduces in-hospital ventricular tachycardia/ventricular fibrillation (VT/VF) in percutaneous coronary intervention (PCI) patients with acute myocardial infarction (MI). Among the 1177 patients from the Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH), 823 (70%) patients received prior statin therapy. Prior statin therapy was associated with a reduced risk of VT/VF events in both adjusted propensity score analysis (odds ratio [OR] 0.414, 95% confidence interval [CI], 0.198-0.865, P = .019) and adjusted inverse probability of treatment weight analysis (OR 0.463, 95% CI, 0.216-0.994, P = .048). The risk of in-hospital death did not differ significantly between those with or without prior statin therapy (hazard ratio [HR] 0.416, 95% CI, 0.112-1.548, P = .191). Major adverse cardiac events occurred in 116 (8.9%) patients during follow-up. Prior statin therapy was associated with a lower risk of major adverse cardiac events during the follow-up period (HR 0.486, 95% CI, 0.243-0.974, P = .042); however, this was mainly driven by reduced noncardiac death. Prior statin therapy might reduce the incidence of serious cardiac tachyarrhythmia, such as VT/VF, in patients with MI undergoing PCI. However, the reduction in VT/VF due to prior statin therapy did not improve short- and long-term clinical outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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