| Autor: |
Racz, Csaba-Pal, Santa, Szabolcs, Tomoaia-Cotisel, Maria, Borodi, Gheorghe, Kacso, Irina, Pirnau, Adrian, Bratu, Ioan |
| Zdroj: |
Journal of Inclusion Phenomena & Macrocyclic Chemistry; Jun2013, Vol. 76 Issue 1-2, p193-199, 7p |
| Abstrakt: |
The inclusion of α-lipoic acid (LA) in β-cyclodextrin (β-CD) by increasing the aqueous solubility and photostability can enhance its medicinal use in the oral administration. Different preparation methods were employed to obtain an α-lipoic acid-β-cyclodextrin (LA-β-CD) inclusion complex and to determine the physical-chemical characteristics and the interactions present in this compound. The formation of the solid inclusion compound was confirmed by X-ray powder diffraction, differential scanning calorimetry (DSC) and infrared spectroscopy (FTIR). FTIR and DSC data confirm the new obtained compound. The crystalline structure of this compound belongs to the monoclinic system with four molecules in the unit cell. H NMR spectroscopic method was employed to study the inclusion process in aqueous solution. Job plots derived from the H NMR spectral data demonstrated an 1:1 stoichiometry of the inclusion complex in liquid state. 2D NMR data suggest the orientation of LA with the carboxyl group near to narrower rim of the β-CD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink