| Autor: |
Skiba, M., Bouchal, F., Boukhris, T., Bounoure, F., Fessi, H., Fatmi, S., Chaffai, N., Lahiani-Skiba, M. |
| Zdroj: |
Journal of Inclusion Phenomena & Macrocyclic Chemistry; Apr2013, Vol. 75 Issue 3-4, p311-314, 4p |
| Abstrakt: |
The objective of this work was to compare the pharmacokinetic parameters of piroxicam-β-cyclodextrin (PIX-CD) complex at molar ratio of 1:1, 1:2.5, 1:3, and 1:4 after an oral administration in rabbits and either to prove or not the Haborn et al. theory which states that the peak plasma concentration (C) of piroxicam increases with an increase of β-cyclodextrin concentration. The results showed an increase in C from 11 ± 1.7, 13.3 ± 6.17 to 17 ± 2.03 μg/ml for piroxicam alone, 1:1 (PIX-CD) and 1:2.5 (PIX-CD), respectively, and declined starting at molar ratio of 1:3 (PIX-CD). However, more rapid drug absorption was observed where the time of peak plasma concentration (T) became shorter and changed from 2 h (Piroxicam alone) to 0.5 h in the presence of cyclodextrin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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