HYBRID SULFONYLUREA-LINKED CHALCONOIDS AS ANTIDIABETIC AGENTS: EVALUATION OF ANTIHYPERGLYCEMIC EFFECTS IN STREPTOZOTOCIN-INDUCED TYPE 2 DIABETIC RATS.

Autor: Raju, D. Bhagya, Rao, A. Vasudeva, Prasad, Y. Rajendra
Předmět:
Zdroj: Rasayan Journal of Chemistry; Jul-Sep2018, Vol. 11 Issue 3, p1334-1338, 5p
Abstrakt: The proposed investigation was carried out to evaluate the antihyperglycemic potential and to explore the structureactivity relationship (SAR) of a series of 28 hybrid sulfonylurea-linked chalconoids using streptozotocin-induced type 2 diabetic rats. Among all the compounds tested, compound SC 21 exhibited remarkable antidiabetic activity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index