| Autor: |
Rao, S. Venkat, Dubey, Rajeev Kumar, Kumar, Ch. Anil, Reddy, M. Sudheer, Narendar, M., Potluri, Ramesh Babu |
| Předmět: |
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| Zdroj: |
Rasayan Journal of Chemistry; Jul-Sep2018, Vol. 11 Issue 3, p1088-1095, 8p |
| Abstrakt: |
Cost effective, robust manufacturing process is developed for N-alkylation of compound 6 and 7 with commercially available reagent/base like DBU, TEA and ethanol used as a solvent. The most important development is high pure pharma product Ticagrelor was achieved by purifying in mixture of Methanol and Water. As per ICH guidelines all known and unknown impurities limits below NMT 0.10% achieved with excellent yield (75%) and Quality 99.9%. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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