Collagen deposition in chronic hidradenitis suppurativa: potential role for CD163+ macrophages.

Autor: Byrd, A. S., Kerns, M. L., Williams, D. W., Zarif, J. C., Rosenberg, A. Z., Delsante, M., Liu, H., Dillen, C. A., Maynard, J. P., Caffrey, J. A., Sacks, J. M., Milner, S. M., Aliu, O., Broderick, K. P., Lew, L. S., Miller, L. S., Kang, S., Okoye, G. A.
Předmět:
Zdroj: British Journal of Dermatology; Sep2018, Vol. 179 Issue 3, p792-794, 3p
Abstrakt: The article offers information on a study which demonstrated potential CD163+ M2 macrophage-mediated carbon-carbon motif chemokine ligand 18 (CCL18) upregulation in hidradenitis suppurativa (HS) and that stimulation of fibroblast-mediated collagen production may play a role in HS disease progression to chronic lesions. It presents information on use of immunohistochemistry (IHC) for determining human tissue resident macrophages (CD68) and M2 macrophages (CD163) infiltration.
Databáze: Complementary Index