Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium.

Autor: Petridou, Eleni Th., Georgakis, Marios K., Erdmann, Friederike, Ma, Xiaomei, Heck, Julia E., Auvinen, Anssi, Mueller, Beth A., Spector, Logan G., Roman, Eve, Metayer, Catherine, Magnani, Corrado, Pombo-de-Oliveira, Maria S., Ezzat, Sameera, Scheurer, Michael E., Mora, Ana Maria, Dockerty, John D., Hansen, Johnni, Kang, Alice Y., Wang, Rong, Doody, David R.
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Zdroj: European Journal of Epidemiology; Oct2018, Vol. 33 Issue 10, p965-976, 12p
Abstrakt: Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (ORCC 1.05, 95% CI 1.00-1.11; ORNCC 1.04, 95% CI 1.01-1.07). A similar positive association with advanced maternal age was observed only in the NCC results (ORCC 0.99, 95% CI 0.91-1.07, heterogeneity I2 = 58%, p = 0.002; ORNCC 1.05, 95% CI 1.01-1.08). The positive association between parental age and risk of ALL was most marked among children aged 1-5 years and remained unchanged following mutual adjustment for the collinear effect of the paternal and maternal age variables; analyses of the relatively small numbers of discordant paternal-maternal age pairs were not fully enlightening. Our results strengthen the evidence that advanced parental age is associated with increased childhood ALL risk; collinearity of maternal with paternal age complicates causal interpretation. Employing datasets with cytogenetic information may further elucidate involvement of each parental component and clarify underlying mechanisms. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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